HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 1-Benzyl-4-(benzylamino)-pyrrolidine-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 1-Benzyl-4-(benzylamino)-pyrrolidine-2-carboxylic acid methyl ester | HCID 67548836 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | 1-Benzyl-4-(benzylamino)-pyrrolidine-2-carboxylic acid | HCID 67546696 | — |
Reaction Steps
1-Benzyl-4-(benzylamino)-pyrrolidine-2-carboxylic acid methyl ester and LiOH are dissolved in THF/H2O, and then stirred overnight. After removal of solvent, the residue is neutralized to PH=6-7, and then extracted by EA. The organic layer is washed with water and brine, dried, and concentrated to afford 1-benzyl-4-(benzylamino)-pyrrolidine-2-carboxylic acid (4).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07528136B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-6fbd808a1da84d5aaba72313f0278eb6 |
| Source note | uspto-grants-2009_05 |