HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzaldehyde → HCID 67549475, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | 1-Tert-butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate | HCID 4913064 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Catalyst | Acetic Acid | HCID 176 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 67549475 | HCID 67549475 | — |
Reaction Steps
To a solution of 4-amino-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester, dissolved in DCM and cooled to 0 centigrade is added a corresponding benzaldehyde, then NaBH(OAc)3 and 5 drops of HOAc. The mixture is warmed to room temperature and stirred overnight. The mixture is diluted with DCM, washed with brine, and dried. After removal of solvent, the crude 4-(benzylamino)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester is obtained (33) and used for the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07528136B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-ddadc9e4ae78492b9bb1be84d3b3ce8d |
| Source note | uspto-grants-2009_05 |