HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 67547818, compound → HCID 57674252, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 67547818 | HCID 67547818 | — |
| Solvent | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| Product | HCID 57674252 | HCID 57674252 | — |
Reaction Steps
{1-Benzyl-5-[4-(2-cyano-phenyl)-piperazine-1-carbonyl]-pyrrolidine-3-yl}carbamic acid tert-butyl ester is dissolved in DCM/CF3COOH and stirred overnight. After removal of solvent, the residue is treated with NaHCO3 and extracted. The organic layer is dried and concentrated to afforded 2-[4-(4-amino-1-benzyl-pyrrolidine-2-carbonyl)-piperazin-1-yl]-benzonitrile (6).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07528136B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-519f21153e334a31b920e52b4bb192ef |
| Source note | uspto-grants-2009_05 |