1-(2-Methoxyethyl)piperazine → [(2s,4s)-1-Benzyl-4-(2,4-difluoro-benzylamino)-pyrrolidin-2-yl]-[4-(2-methoxy-ethyl)-piperazin-1-yl]-methanone

Participants

Reaction Steps

As described for Example 1f, 1-benzyl-4-[tert-butoxycarbonyl-(2,4-difluoro-benzyl)-amino]-pyrrolidine-2-carboxylic acid (60.0 mg, 0.134 mmol) was converted, using 1-(2-methyoxy-ethyl)-piperazine instead of 2-piperazin-1-yl-benzonitrile, to the title compound (5.7 mg, 8.9%) as light yellow oil. MS m/e=473.4 [M+H]+.

Provenance & Evidence