1-(3-(Trifluoromethyl)phenyl)piperazine → [(2S,4S)-1-Benzyl-4-(2,4-difluoro-benzylamino)-pyrrolidin-2-yl]-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone

Participants

Reaction Steps

As described for Example 1f, 1-benzyl-4-[tert-butoxycarbonyl-(2,4-difluoro-benzyl)-amino]-pyrrolidine-2-carboxylic acid (60.0 mg, 0.134 mmol) was converted, using 1-(3-trifluoromethyl-phenyl)piperazine instead of 2-piperazin-1-yl-benzonitrile, to the title compound (8.2 mg, 11%) as light yellow oil. MS m/e=559.4 [M+H]+.

Provenance & Evidence