[5-(3-pyrrolidin-1-yl-propyl)-1H-indol-2-yl]-methanol → 5-(3-pyrrolidin-1-yl-propyl)-1H-indole-2-carbaldehyde

Participants

Reaction Steps

Manganese (IV) oxide (4.7 g, 54 mmol) was added to a mixture of [5-(3-pyrrolidin-1-yl-propyl)-1H-indol-2-yl]-methanol (940 mg, 3.6 mmol) in dichloromethane (150 mL) and toluene (150 mL). The mixture was stirred at room temperature for overnight. The reaction was filtered through a pad of celite and the filtrate was concentrated to give 670 mg (72%) of 5-(3-pyrrolidin-1-yl-propyl)-1H-indole-2-carbaldehyde.

Provenance & Evidence