1-Phenylpiperazine → [(2S,4S)-1-Benzyl-4-(2,4-difluoro-benzylamino)-pyrrolidin-2-yl]-(4-phenyl-piperazin-1-yl)-methanone

Participants

Reaction Steps

As described for Example 1f, 1-benzyl-4-[tert-butoxycarbonyl-(2,4-difluoro-benzyl)-amino]-pyrrolidine-2-carboxylic acid (60.0 mg, 0.134 mmol) was converted, using 1-phenyl-piperazine instead of 2-piperazin-1-yl-benzonitrile, to the title compound (6.3 mg, 9.5%) as light yellow oil. MS m/e=491.4 [M+H]+.

Provenance & Evidence