6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline → HCID 25121363, compound

HRID 490606Notes

Reaction equation

HRID 490606 reaction equation
[CH2:1]([N:8]1[CH2:12][CH:11]([N:13](C(OC(C)(C)C)=O)[CH2:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=2[F:22])[CH2:10][CH:9]1[C:30](O)=[O:31])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:33][O:34][C:35]1[CH:36]=[C:37]2[C:42](=[CH:43][C:44]=1[O:45][CH3:46])[CH2:41][NH:40][CH2:39][CH2:38]2>>[CH2:1]([N:8]1[CH2:12][C@@H:11]([NH:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=2[F:22])[CH2:10][C@H:9]1[C:30]([N:40]1[CH2:39][CH2:38][C:37]2[C:42](=[CH:43][C:44]([O:45][CH3:46])=[C:35]([O:34][CH3:33])[CH:36]=2)[CH2:41]1)=[O:31])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 156236,7-Dimethoxy-1,2,3,4-TetrahydroisoquinolineHCID 675474701-Benzyl-4-[tert-butoxycarbonyl-(2,4-difluoro-benzyl)-amino]-pyrrolidine-2-carboxylic acid

Product 1

HCID 25121363HCID 25121363, compoundYield 5%

Procedure

As described for Example 1f, 1-benzyl-4-[tert-butoxycarbonyl-(2,4-difluoro-benzyl)-amino]-pyrrolidine-2-carboxylic acid (60.0 mg, 0.134 mmol) was converted, using 6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline instead of 2-piperazin-1-yl-benzonitrile, to the title compound (3.5 mg, 5.0%) as light yellow oil. MS m/e=522.4 [M+H]+.

Sources & evidence

ORD record
ord-32c9ad8f503249ea810de60527553995
Source dataset
uspto-grants-2009_05
Patent number
US07528136B2

Reaction notes

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