1-(3,5-Dimethoxyphenyl)piperazine → HCID 67548837, compound

HRID 490610Notes

Reaction equation

HRID 490610 reaction equation
[CH2:1]([N:8]1[CH2:12][CH:11]([N:13](C(OC(C)(C)C)=O)[CH2:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=2[F:22])[CH2:10][CH:9]1[C:30](O)=[O:31])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:33][O:34][C:35]1[CH:36]=[C:37]([N:43]2[CH2:48][CH2:47][NH:46][CH2:45][CH2:44]2)[CH:38]=[C:39]([O:41][CH3:42])[CH:40]=1>>[CH2:1]([N:8]1[CH2:12][C@@H:11]([NH:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=2[F:22])[CH2:10][C@H:9]1[C:30]([N:46]1[CH2:45][CH2:44][N:43]([C:37]2[CH:38]=[C:39]([O:41][CH3:42])[CH:40]=[C:35]([O:34][CH3:33])[CH:36]=2)[CH2:48][CH2:47]1)=[O:31])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27362051-(3,5-Dimethoxyphenyl)piperazineHCID 675474701-Benzyl-4-[tert-butoxycarbonyl-(2,4-difluoro-benzyl)-amino]-pyrrolidine-2-carboxylic acid

Product 1

HCID 67548837HCID 67548837, compoundYield 3.1%

Procedure

As described for Example 1f, 1-benzyl-4-[tert-butoxycarbonyl-(2,4-difluoro-benzyl)-amino]-pyrrolidine-2-carboxylic acid (60.0 mg, 0.134 mmol) was converted, using 1-(3,5-dimethoxy-phenyl)-piperazine instead of 2-piperazin-1-yl-benzonitrile, to the title compound (2.3 mg, 3.1%) as light yellow oil. MS m/e=551.5 [M+H]+.

Sources & evidence

ORD record
ord-5446802d6b3f42359f5b4ac93091e6cf
Source dataset
uspto-grants-2009_05
Patent number
US07528136B2

Reaction notes

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