1-(3,4-Xylyl)piperazine → HCID 68861020, compound

Participants

Reaction Steps

As described for Example 1f, 1-benzyl-4-[tert-butoxycarbonyl-(2,4-difluoro-benzyl)-amino]-pyrrolidine-2-carboxylic acid (60.0 mg, 0.134 mmol) was converted, using 1-(3,4-dimethyl-phenyl)-piperazine instead of 2-piperazin-1-yl-benzonitrile, to the title compound (9.7 mg, 14%) as light yellow oil. MS m/e=519.4 [M+H]+.

Provenance & Evidence