1-(2-Methoxyphenyl)piperazine → {(2S,4S)-1-Benzyl-4-[(3,5-bis-trifluoromethyl-benzyl)-methyl-amino]-pyrrolidin-2-yl}-[4-(2-methoxy-phenyl)-piperazin-1-yl]-methanone

Participants

Reaction Steps

As described for Example 56b and 56d, 1-benzyl-4-oxo-pyrrolidine-2-carboxylic acid methyl ester (100 mg, 0.428 mmol) was converted, using (3,5-bis-trifluoromethyl-benzyl)-methyl-amine instead of 3,5-bis-trifluoromethyl-benzylamine, and using 1-(2-methoxy-phenyl)-piperazine instead of 1-(3-trifluoromethyl-phenyl)-piperazine, to the title compound (11.3 mg, 12.2%) as light yellow oil. MS m/e=635.5 [M+H]+.

Provenance & Evidence