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1-Piperazinecarboxylic acid, ethyl ester → 4-[(2S,4S)-1-Benzyl-4-(3,5-bis-trifluoromethyl-benzylamino)-pyrrolidine-2-carbonyl]-piperazine-1-carboxylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Piperazinecarboxylic acid, ethyl ester | HCID 8431 | — |
| 反応物 | 1-Benzyl-4-(3,5-bis-trifluoromethyl-benzylamino)-pyrrolidine-2-carboxylic acid | HCID 86625301 | — |
| 生成物 | 4-[(2S,4S)-1-Benzyl-4-(3,5-bis-trifluoromethyl-benzylamino)-pyrrolidine-2-carbonyl]-piperazine-1-carboxylic acid ethyl ester | HCID 86625304 | 7.5% |
反応手順
As described for Example 56d, 1-benzyl-4-(3,5-bis-trifluoromethyl-benzylamino)-pyrrolidine-2-carboxylic acid (65 mg, 0.146 mmol) was converted, using piperazine-1-carboxylic acid ethyl ester instead of 1-(3-trifluoromethyl-phenyl)-piperazine, to the title compound (6.8 mg, 7.5%) as light yellow oil. MS m/e=587.3 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07528136B2 |
| 出典データセット | uspto-grants-2009_05 |
| ORD ID | ord-4b477f8ea26b4172bc8be83426e421b5 |
| 出典メモ | uspto-grants-2009_05 |