1-(m-Tolyl)piperazine → [(2s,4s)-1-Benzyl-4-(3,5-bis-trifluoromethyl-benzylamino)-pyrrolidin-2-yl]-(4-m-tolyl-piperazin-1-yl)-methanone

Participants

Reaction Steps

As described for Example 56d, 1-benzyl-4-(3,5-bis-trifluoromethyl-benzylamino)-pyrrolidine-2-carboxylic acid (65 mg, 0.146 mmol) was converted, using 1-m-tolyl-piperzine instead of 1-(3-trifluoromethyl-phenyl)-piperazine, to the title compound (7.5 mg, 8.5%) as light yellow oil. MS m/e=605.4 [M+H]+.

Provenance & Evidence