HRID490639

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2735875

1-(2-Cyanophenyl)piperazine

C11H13N3

结构：CN(Cc1ccc(F)cc1F)[C@H]1C[C@@H](C(=O)O)N(Cc2cccc(Cl)c2)C1

HCID67547489

未命名化合物

PRODUCTS

生成物

结构：CN(Cc1ccc(F)cc1F)[C@H]1C[C@@H](C(=O)N2CCN(c3ccccc3C#N)CC2)N(Cc2cccc(Cl)c2)C1

HCID67547783

未命名化合物

收率 9%

PROCEDURE

实验过程

As described for Example 64e, (2S,4S)-1-(3-Chloro-benzyl)-4-[(2,4-difluoro-benzyl)-methyl-amino]-pyrrolidine-2-carboxylic acid (1 mmol) was converted, using 2-piperazin-1-yl-benzonitrile instead of 2-cyclohexyl-1,3,8-triaza-spiro[4.5]dec-1-en-4-one, to the title compound (51 mg) in 9% yield as colorless oil. MS m/e=565.1 [M+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1e909ccdd1244dc587e18efb1320628d
来源数据集: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07528136B2
来源说明: uspto-grants-2009_05

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][CH:27]=1)[CH2:5][N:6]1[CH2:10][C@@H:9]([N:11]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[F:21])[CH3:12])[CH2:8][C@H:7]1[C:22]([OH:24])=O.[N:28]1([C:34]2[CH:41]=[CH:40][CH:39]=[CH:38][C:35]=2[C:36]#[N:37])[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][CH:27]=1)[CH2:5][N:6]1[CH2:10][C@@H:9]([N:11]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[F:21])[CH3:12])[CH2:8][C@H:7]1[C:22]([N:31]1[CH2:30][CH2:29][N:28]([C:34]2[CH:41]=[CH:40][CH:39]=[CH:38][C:35]=2[C:36]#[N:37])[CH2:33][CH2:32]1)=[O:24]