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HRID 49064作成日：2026年10月25日
Piperidine → 3-[5-(2-dimethylamino-ethoxy)-1H-indol-2-ylmethylene]-5-phenyl-1,3-dihydro-indol-2-one
https://huagongshe.com/reaction/49064
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 5-Phenyloxindole | HCID 13301978 | — |
| 反応物 | 5-(2-dimethylamino-ethoxy)-1H-indole-2-carbaldehyde | HCID 22042141 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-[5-(2-dimethylamino-ethoxy)-1H-indol-2-ylmethylene]-5-phenyl-1,3-dihydro-indol-2-one | HCID 69587436 | 68.5% |
反応手順
A mixture of 5-phenyl-2-oxindole (41 mg, 0.2 mmol), 5-(2-dimethylamino-ethoxy)-1H-indole-2-carbaldehyde (46 mg, 0.2 mmol) and piperidine (0.1 mL) in ethanol (1 mL) was heated at 100° C. for 2 hours. The precipitate was collected by vacuum filtration, washed with ethanol and dried to give 58 mg (68%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06706709B2 |
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| 出典データセット | uspto-grants-2004_03 |
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| ORD ID | ord-5d2ded59db3f47088ddefba486b03a8d |
|---|
| 出典メモ | uspto-grants-2004_03 |
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