1-(2-Methoxyphenyl)piperazine → HCID 67548055, compound

HRID 490640Notes

Reaction equation

HRID 490640 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][CH:27]=1)[CH2:5][N:6]1[CH2:10][C@@H:9]([N:11]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[F:21])[CH3:12])[CH2:8][C@H:7]1[C:22]([OH:24])=O.[CH3:28][O:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=1[N:36]1[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][CH:27]=1)[CH2:5][N:6]1[CH2:10][C@@H:9]([N:11]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[F:21])[CH3:12])[CH2:8][C@H:7]1[C:22]([N:39]1[CH2:38][CH2:37][N:36]([C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=2[O:29][CH3:28])[CH2:41][CH2:40]1)=[O:24]

Participants

3

Reactant 2

HCID 13461-(2-Methoxyphenyl)piperazineHCID 67547489HCID 67547489, compound

Product 1

HCID 67548055HCID 67548055, compoundYield 7%

Procedure

As described for Example 64e, (2S,4S)-1-(3-chloro-benzyl)-4-[(2,4-difluoro-benzyl)-methyl-amino]-pyrrolidine-2-carboxylic acid (1 mmol) was converted, using 1-(2-methoxy-phenyl)-piperazine instead of 2-cyclohexyl-1,3,8-triaza-spiro[4.5]dec-1-en-4-one, to the title compound (40 mg) in 7% yield as colorless oil. MS m/e=570.1 [M+H]+.

Sources & evidence

ORD record
ord-4c70c2a64c50434998650bc89f90411a
Source dataset
uspto-grants-2009_05
Patent number
US07528136B2

Reaction notes

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