1-(m-Tolyl)piperazine → HCID 86625312, compound

Participants

Reaction Steps

As described for Example 64e, (2S,4S)-4-[(3,5-bis-trifluoromethyl-benzyl)-methyl-amino]-1-(3-chloro-benzyl)-pyrrolidine-2-carboxylic acid (1 mmol) was converted, using 4-m-tolyl-piperazine instead of 2-cyclohexyl-1,3,8-triaza-spiro[4.5]dec-1-en-4-one, to the title compound (52.3 mg) in 8% yield as colorless oil. MS m/e=654.1 [M+H]+.

Provenance & Evidence