1-(3-(Trifluoromethyl)phenyl)piperazine → HCID 86625315, compound

HRID 490650Notes

Reaction equation

HRID 490650 reaction equation
[F:1][C:2]([F:33])([F:32])[C:3]1[CH:4]=[C:5]([CH:25]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:27]=1)[CH2:6][N:7]([CH3:24])[C@@H:8]1[CH2:12][N:11]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[C@H:10]([C:21](O)=[O:22])[CH2:9]1.[F:34][C:35]([F:49])([F:48])[C:36]1[CH:37]=[C:38]([N:42]2[CH2:47][CH2:46][NH:45][CH2:44][CH2:43]2)[CH:39]=[CH:40][CH:41]=1>>[F:33][C:2]([F:1])([F:32])[C:3]1[CH:4]=[C:5]([CH:25]=[C:26]([C:28]([F:29])([F:30])[F:31])[CH:27]=1)[CH2:6][N:7]([CH3:24])[C@@H:8]1[CH2:12][N:11]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[C@H:10]([C:21]([N:45]2[CH2:46][CH2:47][N:42]([C:38]3[CH:39]=[CH:40][CH:41]=[C:36]([C:35]([F:34])([F:48])[F:49])[CH:37]=3)[CH2:43][CH2:44]2)=[O:22])[CH2:9]1

Participants

3

Reactant 2

HCID 42961-(3-(Trifluoromethyl)phenyl)piperazineHCID 86625314HCID 86625314, compound

Product 1

HCID 86625315HCID 86625315, compoundYield 10%

Procedure

As described for Example 64e, (2S,4S)-4-[(3,5-bis-trifluoromethyl-benzyl)-methyl-amino]-1-(4-chloro-benzyl)-pyrrolidine-2-carboxylic acid (1 mmol) was converted, using 1-(3-trifluoromethyl-phenyl)-piperazine instead of 2-cyclohexyl-1,3,8-triaza-spiro[4.5]dec-1-en-4-one, to the title compound (70.8 mg) in 10% yield as colorless oil. MS m/e=708.1 [M+H]+.

Sources & evidence

ORD record
ord-8c23e6c753bf49a1aed77dfe1262a71a
Source dataset
uspto-grants-2009_05
Patent number
US07528136B2

Reaction notes

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