HCID 67547818, compound → HCID 57674252, compound

Participants

Reaction Steps

{1-Benzyl-5-[4-(2-cyano-phenyl)-piperazine-1-carbonyl]-pyrrolidine-3-yl}carbamic acid tert-butyl ester (2 g, 4 mmol) was dissolved in 15 mL DCM/CF3COOH (2:1), stirred overnight. After removal of solvent, the residue was treated with saturated NaHCO3, extracted with EA (2×100 mL). The organic layer was dried over Na2SO4, concentrated to afforded title product 2-[4-(4-amino-1-benzyl-pyrrolidine-2-carbonyl)-piperazin-1-yl]-benzonitrile 1.6 g (100%) as brown oil. MS m/e=390.2 [M+H]+.

Provenance & Evidence