Benzoyl chloride, 3-chloro- → HCID 67546793, compound

HRID 490667Notes

Reaction equation

HRID 490667 reaction equation
[NH2:1][CH:2]1[CH2:6][N:5]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:4]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[CH:29]=[CH:28][CH:27]=[CH:26][C:23]=3[C:24]#[N:25])[CH2:18][CH2:17]2)=[O:15])[CH2:3]1.[Cl:30][C:31]1[CH:32]=[C:33]([CH:37]=[CH:38][CH:39]=1)[C:34](Cl)=[O:35]>>[CH2:7]([N:5]1[C@H:4]([C:14]([N:16]2[CH2:17][CH2:18][N:19]([C:22]3[CH:29]=[CH:28][CH:27]=[CH:26][C:23]=3[C:24]#[N:25])[CH2:20][CH2:21]2)=[O:15])[CH2:3][C@H:2]([NH:1][C:34](=[O:35])[C:33]2[CH:37]=[CH:38][CH:39]=[C:31]([Cl:30])[CH:32]=2)[CH2:6]1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 69252Benzoyl chloride, 3-chloro-HCID 57674252HCID 57674252, compound

Product 1

HCID 67546793HCID 67546793, compoundYield 6.4%

Procedure

As described for Example 89e, 2-[4-(4-amino-1benzyl-pyrrolidine-2-carbonyl)-piperazin-1-yl]-benzonitrile (50.0 mg, 0.128 mmol) was converted, using 3-chloro-benzoyl chloride instead of 2-chloro-benzoyl chloride, to the title compound (4.3 mg, 6.4%) as light yellow oil. MS m/e=528.3 [M+H]+.

Sources & evidence

ORD record
ord-27658f7cc8ba41379b11e1cb88b2fb65
Source dataset
uspto-grants-2009_05
Patent number
US07528136B2

Reaction notes

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