HCID 19097360, compound → HCID 19097335, compound

HRID 490678Notes

Reaction equation

HRID 490678 reaction equation
[CH2:1]([O:3][C:4](=[O:24])[CH:5]([N:7]1[C:15]2[C:10](=[CH:11][C:12]([O:16]CC3C=CC=CC=3)=[CH:13][CH:14]=2)[CH:9]=[CH:8]1)[CH3:6])[CH3:2].[H][H]>C(O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:24])[CH:5]([N:7]1[C:15]2[C:10](=[CH:11][C:12]([OH:16])=[CH:13][CH:14]=2)[CH:9]=[CH:8]1)[CH3:6])[CH3:2]

Participants

5

Reactant 2

HCID 19097360HCID 19097360, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 19097335HCID 19097335, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 2-(5-Benzyloxy-indol-1-yl)-propionic acid ethyl ester (16 g) and Pd/C (5%, 1.93 g) in ethanol (190 mL) is stirred under 60 PSI of hydrogen overnight. Filtration and concentration yields the title compound.

Workup

  1. filtrationFiltration and concentration

Sources & evidence

ORD record
ord-52bd044d31734d86a0d16dcb02fd6a33
Source dataset
uspto-grants-2009_05
Patent number
US07528160B2

Reaction notes

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