反应详情

To a solution of 3-oxo-5-phenyl-pentanoic acid ethyl ester (1.6 g, 7.76 mmol) in methylene chloride (18 mL) is added sulfuryl chloride (1.15 g, 8.53 mmol) dropwise. After stirred at room temperature for 6 hours, the reaction mixture is poured into water, extracted with methylene chloride, washed wished water and brine, dried over sodium sulfate. Concentration yields the crude title compounds, which is used for the next step without further purification.

1. extractionextracted with methylene chloride
2. washwashed
3. dry with materialdried over sodium sulfate
4. concentrationConcentration