HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Azidomethyl-5-methyl-2-(4-trifluoromethyl-phenyl)-oxazole → C-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-methylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Azidomethyl-5-methyl-2-(4-trifluoromethyl-phenyl)-oxazole | HCID 58765728 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | C-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-methylamine | HCID 58765787 | 84.2% |
Reaction Steps
A mixture of 4-azidomethyl-5-methyl-2-(4-trifluoromethyl-phenyl)-oxazole (1.70 g) and PtO2 (0.106 g) in ethyl acetate (50 mL) at room temperature under 60 psi of hydrogen for 5 hrs, the reaction mixture is filtered through celite and filtrate is concentrated giving the title compound (1.3 g, 84.2% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07528160B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-47e393fd217a44e9a6c6d06458a848f4 |
| Source note | uspto-grants-2009_05 |