HCID 57675476, compound → HCID 57675471, compound

HRID 490756Notes

Reaction equation

HRID 490756 reaction equation
[CH2:1]([O:3][C:4](=[O:25])[C:5]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([O:17]CC3C=CC=CC=3)=[CH:14][CH:15]=2)[CH:10]=[CH:9]1)([CH3:7])[CH3:6])[CH3:2].[H][H]>C(O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:25])[C:5]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([OH:17])=[CH:14][CH:15]=2)[CH:10]=[CH:9]1)([CH3:7])[CH3:6])[CH3:2]

Participants

5

Reactant 2

HCID 57675476HCID 57675476, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 57675471HCID 57675471, compoundYield 96.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 2-(5-benzyloxy-indol-1-yl)-2-methyl-propionic acid ethyl ester (15.6 g) and Pd/C (5%, 1.93 g) in ethanol (190 mL) is stirred under 60 PSI of hydrogen overnight. Filtration and concentration yields the title compound (11 g).

Workup

  1. filtrationFiltration and concentration

Sources & evidence

ORD record
ord-4d22db533e9649e4901fe438595441b1
Source dataset
uspto-grants-2009_05
Patent number
US07528160B2

Reaction notes

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