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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 49077Generated: October 27, 2026

Piperidine → 3-[5-(2-Diethylamino-ethoxy)-1H-indol-2-ylmethylene]-6-phenyl-1,3-dihydro-indol-2-one

https://huagongshe.com/reaction/49077

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPiperidineHCID 8082—
Reactant6-Phenyl-1,3-dihydro-indol-2-oneHCID 10536384—
Reactant5-(2-diethylamino-ethoxy)-1H-indole-2-carbaldehydeHCID 22042099—
SolventEthanolHCID 702—
Product3-[5-(2-Diethylamino-ethoxy)-1H-indol-2-ylmethylene]-6-phenyl-1,3-dihydro-indol-2-oneHCID 6958678172%

Reaction Conditions

Temperature100 °C

Reaction Steps

A mixture of 6-phenyl-2-oxindole (40.5 mg, 0.2 mmol), 5-(2-diethylamino-ethoxy)-1H-indole-2-carbaldehyde (50 mg, 0.2 mmol) and piperidine (0.1 mL) in ethanol (1 mL) was heated at 100° C. for 2 hours. The precipitate was collected by vacuum filtration, washed with ethanol and dried to give 65 mg (72%) of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06706709B2
Source datasetuspto-grants-2004_03
ORD IDord-cc8d903ff1ac405da627034a62d2627e
Source noteuspto-grants-2004_03