1,2-Dichloroethane → N-(3,3-Dimethylbutyl)-3-(2,2-dimethyl-1-oxopropyl)-N-ethyl-6-methoxy-1H-indazole-1-acetamide

Participants

Reaction Steps

To a solution of 29.0 mg [3-(2,2-dimethylpropanoyl)-6-methoxy-1H-indazol-1-yl]acetic acid in 1 mL DMF was added 23.0 mg HOBt, 32.3 mg N-Ethyl-3,3-dimethylbutan-1-lamine hydrochloride from the Step A above, 38.3 mg EDC, and 45.2 mg DIEA in that order. The mixture was stirred at room temperature for four hours and heated at 45° C. over night and purified by RP-HPLC using 70-100% MeCN gradient. The pure product fractions were pooled and lyophilized to give the title compound. LC-MS: 4.29 min. (m/Z=402.4, 424.3).

Provenance & Evidence