Malononitrile → 2-Amino-4-(5-bromo-pyridin-3-yl)-3-cyano-7-methyl-4H-pyrrolo [2,3-h]chromene

Participants

Reaction Steps

The title compound was prepared from 5-bromo-pyridine-3-carbaldehyde (44 mg, 0.24 mmol), 4-hydroxy-1-methyl-indole (35 mg, 0.24 mmol), malononitrile (16 mg, 0.24 mmol) and piperidine (0.05 mL), similar to Example 10, and isolated as a solid. 1H NMR (CDCl3): 8.54 (d, J=2.4 Hz, 1H), 8.47 (d, J=1.8 Hz, 1H), 7.60 (m, 1H), 7.08 (d, J=3.0 Hz, 1H), 7.05 (d, J=8.4 Hz, 1H), 6.70 (d, J=8.7 Hz, 1H), 6.58 (d, J=3.0 Hz, 1H), 4.89 (s, 1H), 4.78 (brs, 2H), 3.79 (s, 3H).

Provenance & Evidence