3-Nitrobenzaldehyde → 2-Amino-3-cyano-4-(3-nitrophenyl)-7-methyl-4H-pyrrolo[2,3-h]chromene

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Reaction Steps

The title compound was prepared from 4-hydroxy-1-methylindole (40 mg, 0.27 mmol), 3-nitrobenzaldehyde (41 mg, 0.27 mmol) and malononitrile (18 mg, 0.27 mmol) similar to Example 24 to yield 61 mg (65%) of white solids. 1H NMR (CDCl3): 8.10 (d, J=7.8 Hz, 1H), 8.05-8.04 (m, 1H), 7.62 (d, J=7.8 Hz, 1H), 7.49 (t, J=7.8 Hz, 1H), 7.08-7.02 (m, 2H), 6.69 (d, J=8.7 Hz, 1H), 6.59 (d, J=3.0 Hz, 1H), 5.00 (s, 1H), 4.76 (s, 2H), 3.78 (s, 3H).

Provenance & Evidence