Malononitrile → 2-Amino-3-cyano-4-(3-methoxyphenyl)-7-methyl-4H-pyrrolo[2,3-h]chromene

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Reaction Steps

The title compound was prepared from 4-hydroxy-1-methylindole (40 mg, 0.27 mmol), 3-methoxybenzaldehyde (38 mg, 0.27 mmol) and malononitrile (18 mg, 0.27 mmol) similar to Example 24 to yield 64 mg (69%) of white solids. 1H NMR (CDCl3): 7.23-7.18 (m, 1H), 7.05-7.00 (m, 2H), 6.83-6.74 (m, 4H), 6.56 (d, J=3.0 Hz, 1H), 4.81 (s, 1H), 4.64 (brs, 2H), 3.76 (s, 6H).

Provenance & Evidence