Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 490832Generated: October 30, 2026

Malononitrile → HCID 10088419, compound

https://huagongshe.com/reaction/490832

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMalononitrileHCID 8010—
Reactant3,5-DifluorobenzaldehydeHCID 588160—
Reactant4-Hydroxy-1-methylindoleHCID 15825739—
ProductHCID 10088419HCID 10088419—

Reaction Steps

The title compound was prepared from 4-hydroxy-1-methylindole (40 mg, 0.27 mmol), 3,5-difluorobenzaldehyde (38 mg, 0.27 mmol) and malononitrile (18 mg, 0.27 mmol) similar to Example 24 to yield 38 mg (42%) of white solids. 1H NMR (CDCl3): 7.07-7.03 (m, 2H), 6.76-6.73 (m, 3H), 6.68-6.62 (m, 1H), 6.57 (d, J=3.0 Hz, 1H), 4.83 (s, 1H), 4.72 (brs, 2H), 3.78 (s, 3H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07528164B2
Source datasetuspto-grants-2009_05
ORD IDord-6d843c10b8d64740b0e42bab449a0dce
Source noteuspto-grants-2009_05