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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 490834Generated: October 30, 2026

Malononitrile → HCID 10336490, compound

https://huagongshe.com/reaction/490834

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMalononitrileHCID 8010—
Reactantm-FormylbenzonitrileHCID 90670—
Reactant4-Hydroxy-1-methylindoleHCID 15825739—
ProductHCID 10336490HCID 10336490—

Reaction Steps

The title compound was prepared from 4-hydroxy-1-methylindole (40 mg, 0.27 mmol), 3-cyanobenzaldehyde (36 mg, 0.27 mmol) and malononitrile (18 mg, 0.27 mmol) similar to Example 24 to yield 87 mg (98%) of white solids. 1H NMR (CDCl3): 7.53-7.39 (m, 4H), 7.08-7.03 (m, 2H), 6.68 (d, J=8.4 Hz, 1H), 6.58 (d, J=3.3 Hz, 1H), 4.90 (s, 1H), 4.74 (brs, 2H), 3.79 (s, 3H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07528164B2
Source datasetuspto-grants-2009_05
ORD IDord-569845268a044150922f389ed3c38afd
Source noteuspto-grants-2009_05