3,4,5-Trimethoxybenzaldehyde → 2-Amino-3-cyano-4-(3,4,5-trimethoxyphenyl)-7-hydroxymethyl-4H-pyrrolo[2,3-h]chromene

Participants

Reaction Steps

The title compound was prepared from 4-hydroxy-1-hydroxymethylindole (30 mg, 0.18 mmol), 3,4,5-trimethoxy-benzaldehyde (36 mg, 0.18 mmol) and malononitrile (12 mg, 0.18 mmol) similar to Example 24 to yield 63 mg (84%) of white solids. 1H NMR (CDCl3): 7.21-7.20 (m, 2H), 6.84 (d, J=8.4 Hz, 1H), 6.64 (d, J=3.0 Hz, 1H), 6.42 (s, 2H), 5.61 (d, J=6.0 Hz, 2H), 4.78 (s, 1H), 4.67 (brs, 2H), 3.82-3.80 (m, 9H), 2.46 (brs, 1H).

Provenance & Evidence