Malononitrile → 2-Amino-3-cyano-4-(3,5-dimethoxyphenyl)-7-hydroxymethyl-4H-pyrrolo [2,3-h]chromene

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Reaction Steps

The title compound was prepared from 4-hydroxy-1-hydroxymethylindole (30 mg, 0.18 mmol), 3,5-dimethoxy-benzaldehyde (31 mg, 0.18 mmol) and malononitrile (12 mg, 0.18 mmol) similar to Example 24 to yield 19 mg (27%) of white solids. 1H NMR (CDCl3): 7.20-7.15 (m, 2H), 6.85 (d, J=8.1 Hz, 1H), 6.62 (d, J=3.3 Hz, 1H), 6.36-6.32 (m, 3H), 5.60 (s, 2H), 4.76 (s, 1H), 4.64 (brs, 2H), 3.75 (s, 6H), 2.43 (brs, 1H).

Provenance & Evidence