Malononitrile → HCID 10448627, compound

Participants

Reaction Steps

To a mixture of 3-fluorobenzaldehyde (46 mg, 0.37 mmol) and malononitrile (25 mg, 0.37 mmol) in ethanol (1 mL) was added 4-hydroxy-1-methyl-indole (55 mg, 0.37 mmol) followed by piperidine (0.02 mL, 0.19 mmol, 0.5 eq.). Reaction mixture was stirred at room temperature overnight. The desired compound precipitated and was collected, washed with ethanol and dried, yielding 36 mg of a yellow solid. 1H NMR (CDCl3): 7.28-7.23 (m, 1H), 7.05-7.01 (m, 3H), 6.92-6.86 (m, 2H), 6.74 (d, J=8.4 Hz, 1H), 6.56 (d, J=3.1 Hz, 1H), 4.84 (s, 1H), 4.67 (s, 2H), 3.76 (s, 3H).

Provenance & Evidence