Malononitrile → 2-Amino-3-cyano-4-(5-methoxy-pyridin-3-yl)-7-methyl-4H-pyrrolo[2,3-h]chromene

Participants

Reaction Steps

The title compound was prepared from 5-methoxy-pyridine-3-carbaldehyde (70 mg, 0.51 mmol), 4-hydroxy-1-methylindole (75 mg, 0.51 mmol), malononitrile (34 mg, 0.51 mmol) and piperidine (0.05 ml, 0.5 mmol) similar to Example 1e to give 21 mg (12%) of white solids. 1H NMR (CDCl3): 8.19-8.15 (m, 2H), 7.07-6.99 (m, 3H), 6.73 (d, J=8.4 Hz, 1H), 6.57 (d, J=3.0 Hz, 1H), 4.89 (s, 1H), 4.75 (brs, 2H), 3.81-3.78 (m, 6H).

Provenance & Evidence