反应详情

温度

50 °C

A solution of Intermediate 16 (37.8 g) in ethanol:water (4:1, 375 ml) was treated with sodium hydroxide (18.9 g). The mixture was heated at 50° C. for 5 hours, then concentrated in vacuo, dissolved in water and acidified to pH 2 with aqueous hydrochloric acid (2M). The resultant white solid was removed by filtration and dried under vacuum to afford Intermediate 17 as an off-white solid (29.65 g). LCMS showed MH+=291; TRET=2.17 min.

1. concentrationconcentrated in vacuo
2. dissolutiondissolved in water
3. customThe resultant white solid was removed by filtration
4. customdried under vacuum