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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 490894Generated: October 27, 2026

phenylalaninol, (S)- → 1-Ethyl-N-[(1S)-2-hydroxy-1-(phenylmethyl)ethyl]-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

https://huagongshe.com/reaction/490894

Reaction equation

Participants

RoleNameHCIDCharge
Reactantphenylalaninol, (S)-HCID 447213—
Reactant1-Ethyl-N-[(1R)-2-hydroxy-1-phenylethyl]-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamideHCID 11281295—
Reactant1-Ethyl-4-((tetrahydro-2H-pyran-4-yl)amino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acidHCID 53487829—
Product1-Ethyl-N-[(1S)-2-hydroxy-1-(phenylmethyl)ethyl]-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamideHCID 57675167—

Reaction Steps

Intermediate 44 was prepared from Intermediate 17 and (2S)-2-amino-3-phenyl-1-propanol (commercially available from Aldrich) using an analogous method to that for Intermediate 42. LCMS showed MH+=424; TRET=2.60 min.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07528148B2
Source datasetuspto-grants-2009_05
ORD IDord-ed8810d8066a404d87394abb2ac3d971
Source noteuspto-grants-2009_05