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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 490896Generated: October 25, 2026

(1S)-2-amino-1-phenylethan-1-ol → 1-Ethyl-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

https://huagongshe.com/reaction/490896

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(1S)-2-amino-1-phenylethan-1-olHCID 643217—
Reactant1-Ethyl-N-[(1R)-2-hydroxy-1-phenylethyl]-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamideHCID 11281295—
Reactant1-Ethyl-4-((tetrahydro-2H-pyran-4-yl)amino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acidHCID 53487829—
Product1-Ethyl-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamideHCID 57675168—

Reaction Steps

Intermediate 48 was prepared from Intermediate 17 and (1S)-2-amino-1-phenylethanol (commercially available from Fluka) using an analogous method to that for Intermediate 42. LCMS showed MH+=410; TRET=2.62 min.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07528148B2
Source datasetuspto-grants-2009_05
ORD IDord-d7b92bef333c496aa76ac118660837a8
Source noteuspto-grants-2009_05