2-Amino-2-methyl-1-propanol → 1-Ethyl-N-(2-hydroxy-1,1-dimethylethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	2-Amino-2-methyl-1-propanol	HCID 11807	—
Reactant	1-Ethyl-N-[(1R)-2-hydroxy-1-phenylethyl]-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide	HCID 11281295	—
Reactant	1-Ethyl-4-((tetrahydro-2H-pyran-4-yl)amino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid	HCID 53487829	—
Product	1-Ethyl-N-(2-hydroxy-1,1-dimethylethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide	HCID 57675183	—

Reaction Steps

Intermediate 49 was prepared from Intermediate 17 and 2-amino-2-methyl-1-propanol (commercially available from Aldrich) using an analogous method to that for Intermediate 42. LCMS showed MH+=362; TRET=2.28 min.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07528148B2
Source dataset	uspto-grants-2009_05
ORD ID	ord-e1170cd929b7488abc692f556a381ce6
Source note	uspto-grants-2009_05