Methyl N-(triethylammoniosulfonyl)carbamate → HCID 57675218, compound

Participants

Reaction Steps

Burgess Reagent 4.53 g, 19.0 mmol) was added to a suspension of Intermediate 136 (5.0 g, 17.3 mmol) in THF (80 ml). The reaction mixture was stirred at room temperature for 18 hours then a further portion of Burgess Reagent (0.9 g, 1.8 mmol) was added and stirring continued for 5 hours. The reaction mixture was concentrated in vacuo and the residue partitioned between dichloromethane and water. The organic phase was washed with water, dried and evaporated in vacuo to afford Intermediate 137 as an off-white solid (4.43 g). LCMS showed MH+=272; TRET=2.40 min

Provenance & Evidence