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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 490914생성일: 2026년 10월 25일

1-Ethyl-N-[(1R)-2-hydroxy-1-phenylethyl]-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide → 1-Ethyl-N-[4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

https://huagongshe.com/reaction/490914

반응식

참여 물질

역할이름HCID투입량
반응물1-Ethyl-N-[(1R)-2-hydroxy-1-phenylethyl]-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamideHCID 11281295—
반응물(4-Aminooxan-4-yl)methanolHCID 18316484—
반응물1-Ethyl-4-((tetrahydro-2H-pyran-4-yl)amino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acidHCID 53487829—
생성물1-Ethyl-N-[4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamideHCID 57675193—

반응 단계

Intermediate 139 was prepared from Intermediate 17 and (4-aminotetrahydro-2H-pyran-4-yl)methanol (commercially available from PharmaCore Inc., 4170 Mendenhall Oaks Pkwy, Suite 140, High point, N.C., USA) using an analogous method to that for Intermediate 42. LCMS showed MH+=404, TRET=2.19 min.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07528148B2
출처 데이터셋uspto-grants-2009_05
ORD IDord-31e5046357f5475c91c21b62a818d1cb
출처 메모uspto-grants-2009_05