HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 490916Generated: October 26, 2026
Lawesson's reagent → N-Cyclopentyl-1-ethyl-5-(5-isopropyl-1,3,4-thiadiazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine
https://huagongshe.com/reaction/490916
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | 4-(Cyclopentylamino)-1-ethyl-N'-isobutyryl-1H-pyrazolo[3,4-b]pyridine-5-carbohydrazide | HCID 57675192 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-Cyclopentyl-1-ethyl-5-(5-isopropyl-1,3,4-thiadiazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine | HCID 57675135 | — |
Reaction Steps
Intermediate 10 was dissolved in acetonitrile (5 ml) then treated with Lawesson's reagent (0.125 g) and heated under nitrogen at 65° C. for 66 h. Volatiles were removed in vacuo and the residue was purified by mass directed autoprep HPLC to afford Example 6. LCMS showed MH+=357; TRET=3.59 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07528148B2 |
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| Source dataset | uspto-grants-2009_05 |
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| ORD ID | ord-5cbff5b52d93484cb6e1203e63befdbb |
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| Source note | uspto-grants-2009_05 |
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