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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 490924Generated: October 30, 2026

Hydrochloric Acid → HCID 67374343, compound

https://huagongshe.com/reaction/490924

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantHCID 67375444HCID 67375444—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 67374343HCID 67374343115.1%

Reaction Conditions

Temperature100 °C

Reaction Steps

To a solution of 2-(1-benzyloxycarbonylpiperidin-4-yl)prop-2-enoic acid ethyl ester (0.40 g, 1.4 mmol) in 1 mL of dioxane was added 5 mL of 6 N HCl. The solution was heated to 100° C. for 18 hours. The reaction mixture was evaporated in vacuo to afford 2-(piperidin-4-yl)prop-2-enoic acid (0.25 g, 100%) as a hydrogen chloride salt.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07528173B2
Source datasetuspto-grants-2009_05
ORD IDord-63c82bc0a96a461489982a91a4eccbf7
Source noteuspto-grants-2009_05