反应详情

温度

0 °C

To a solution of α-hydroxy-3-nitrobenzeneacetonitrile (27.8 g, 156.1 mmol) in 500 mL of ether was added methanol (7.6 mL, 187.3 mmol). Hydrogen chloride gas was bubbled into the solution until it was saturated. The solution changed to a heterogeneous solution. The solution was cooled to 0° C. and filtered to collect the solid. The filtrate was extracted with methylene chloride, dried over sodium sulfate, filtered and concentrated to afford 25.0 g (76%) of 2-hydroxy-2-(3-nitrophenyl)ethanoic acid methyl ester, a compound of formula (S), as a yellow solid.

1. customHydrogen chloride gas was bubbled into the solution until it
2. filtrationfiltered
3. customto collect the solid
4. extractionThe filtrate was extracted with methylene chloride
5. dry with materialdried over sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated