5-(2-pyrrolidin-1-yl-ethoxy)-1H-indole-2-carbaldehyde → 2-Oxo-3-[5-(2-pyrrolidin-1-yl-ethoxy)-1H-indol-2-ylmethylene]-2,3-dihydro-1H-indole-5-sulfonic acid (3-chloro-phenyl)-methyl-amide

HRID 49095Notes

Reaction equation

HRID 49095 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]([CH3:22])[S:9]([C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][CH:20]=2)[NH:17][C:16](=[O:21])[CH2:15]3)(=[O:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.[N:23]1([CH2:28][CH2:29][O:30][C:31]2[CH:32]=[C:33]3[C:37](=[CH:38][CH:39]=2)[NH:36][C:35]([CH:40]=O)=[CH:34]3)[CH2:27][CH2:26][CH2:25][CH2:24]1>>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]([CH3:22])[S:9]([C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][CH:20]=2)[NH:17][C:16](=[O:21])[C:15]3=[CH:40][C:35]2[NH:36][C:37]3[C:33]([CH:34]=2)=[CH:32][C:31]([O:30][CH2:29][CH2:28][N:23]2[CH2:27][CH2:26][CH2:25][CH2:24]2)=[CH:39][CH:38]=3)(=[O:11])=[O:10])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 220420925-(2-pyrrolidin-1-yl-ethoxy)-1H-indole-2-carbaldehydeHCID 44627952N-(3-chlorophenyl)-N-methyl-2-oxoindoline-5-sulfonamide

Product 1

HCID 698984512-Oxo-3-[5-(2-pyrrolidin-1-yl-ethoxy)-1H-indol-2-ylmethylene]-2,3-dihydro-1H-indole-5-sulfonic acid (3-chloro-phenyl)-methyl-amide

Procedure

2-Oxo-2,3-dihydro-1H-indole-5-sulfonic acid (3-chloro-phenyl)-methyl-amide was condensed with 5-(2-pyrrolidin-1-yl-ethoxy)-1H-indole-2-carbaldehyde to give the title compound.

Sources & evidence

ORD record
ord-12f638ffe9e949e99e5e28a062188c8f
Source dataset
uspto-grants-2004_03
Patent number
US06706709B2

Reaction notes

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