Pyridine → HCID 86596236, compound

Participants

Reaction Steps

A solution of N -[2-(2-bromoethylcarbamylthio)benzoyl]-β-alaninamide (0.37 g, 1.0 mmol) in pyridine (5 ml) was stirred for 8 h under nitrogen. The pyridine was removed in vacuo, and the crude product was purified by column chromatography on silica using chloroform-methanol(7:3 v/v) as eluent. Yield: 82%. 1H NMR (DMSO-d6): 2.38(t, 2H, CH2), 3.40(q, 2H, CH2), 3.72(q,2H, CH2), 4.72(t, 2H, CH2), 6.92(brs, 1H, NH2), 7.36-7.58(m, 5H, Ar—H, NH2), 8.26(t, 2H, Py-H), 8.36(t, 1H, NH), 8.66(t, 1H, Py-H), 9.12(d, 2H, Py-H).

Provenance & Evidence