反应详情

To a solution of 4-phenoxyphenylacetic acid (1.0 g, 4.38 mmoles) in methanol (5.0 ml) was added concentrated sulfuric acid (0.05 ml, 0.88 mmoles) and the mixture was heated to reflux for about 5 hours. The mixture was cooled and concentrated under reduced pressure. To the residue was added a saturated aqueous solution of sodium bicarbonate (20.0 ml) and the mixture was extracted with ethyl acetate. The combined organic extracts were washed with water and brine, dried over MgSO4, filtered and evaporated to dryness to afford the title compound.

1. temperaturethe mixture was heated
2. temperatureto reflux for about 5 hours
3. temperatureThe mixture was cooled
4. concentrationconcentrated under reduced pressure
5. additionTo the residue was added a saturated aqueous solution of sodium bicarbonate (20.0 ml)
6. extractionthe mixture was extracted with ethyl acetate
7. washThe combined organic extracts were washed with water and brine
8. dry with materialdried over MgSO4
9. filtrationfiltered
10. customevaporated to dryness