HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-2-nitro-3-(trifluoromethyl)benzene → 2-Amino-3-methylbenzotrifluoride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-2-nitro-3-(trifluoromethyl)benzene | HCID 13455431 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Amino-3-methylbenzotrifluoride | HCID 13318233 | — |
Reaction Steps
A suspension of 50 g (0.24 mol) 1-methyl-2-nitro-3-trifluoromethyl-benzene and 4.4 g 10% Pd/C in 300 mL MeOH was hydrogenated at RT and 3000 hPa hydrogen pressure until the theoretical amount of hydrogen had been taken up. The catalyst was filtered off, washed with MeOH and the filtrate was evaporated down. The crude product was further reacted without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07528129B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-2e76dbfa524e4d0db4d230b5fb152532 |
| Source note | uspto-grants-2009_05 |