HRID491162

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21942315

1-(Oxan-4-yl)piperazine

C9H18N2O

结构：Nc1c(Cl)cc(C[C@@H](CC(=O)N2CCC(N3Cc4cc(O)ccc4NC3=O)CC2)C(=O)O)cc1C(F)(F)F

HCID68676153

未命名化合物

PRODUCTS

生成物

结构：Nc1c(Cl)cc(C[C@@H](CC(=O)N2CCC(N3Cc4cc(O)ccc4NC3=O)CC2)C(=O)N2CCN(C3CCOCC3)CC2)cc1C(F)(F)F

HCID57674019

未命名化合物

PROCEDURE

实验过程

Prepared analogously to Example 81 from 80.0 mg (0.14 mmol) (S)-2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-4-[4-(6-hydroxy-2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-4-oxo-butanoic acid and 24.5 mg (0.14 mmol) 1-(tetrahydropyran-4-yl)-piperazine.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-af55537840354304926fb2cbda654202
来源数据集: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07528129B2
来源说明: uspto-grants-2009_05

反应 SMILES

[NH2:1][C:2]1[C:33]([C:34]([F:37])([F:36])[F:35])=[CH:32][C:5]([CH2:6][C@@H:7]([CH2:11][C:12]([N:14]2[CH2:19][CH2:18][CH:17]([N:20]3[CH2:29][C:28]4[C:23](=[CH:24][CH:25]=[C:26]([OH:30])[CH:27]=4)[NH:22][C:21]3=[O:31])[CH2:16][CH2:15]2)=[O:13])[C:8](O)=[O:9])=[CH:4][C:3]=1[Cl:38].[O:39]1[CH2:44][CH2:43][CH:42]([N:45]2[CH2:50][CH2:49][NH:48][CH2:47][CH2:46]2)[CH2:41][CH2:40]1>>[NH2:1][C:2]1[C:33]([C:34]([F:37])([F:36])[F:35])=[CH:32][C:5]([CH2:6][C@@H:7]([CH2:11][C:12]([N:14]2[CH2:19][CH2:18][CH:17]([N:20]3[CH2:29][C:28]4[C:23](=[CH:24][CH:25]=[C:26]([OH:30])[CH:27]=4)[NH:22][C:21]3=[O:31])[CH2:16][CH2:15]2)=[O:13])[C:8]([N:48]2[CH2:47][CH2:46][N:45]([CH:42]3[CH2:43][CH2:44][O:39][CH2:40][CH2:41]3)[CH2:50][CH2:49]2)=[O:9])=[CH:4][C:3]=1[Cl:38]