HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 5-Isopropylaminosulfonyl-2-oxindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | 2-oxo-2,3-dihydro-1H-indole-5-sulfonyl chloride | HCID 4962506 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Isopropylaminosulfonyl-2-oxindole | HCID 21915610 | 45.5% |
Reaction Steps
A suspension of 3 g of 5-chlorosulfonyl-2-oxindole, 1.15 g of isopropylamine and 1.2 mL of pyridine in 50 mL of dichloromethane was stirred at room temperature for 4 hours at which time a white solid was present. The precipitate was collected by vacuum filtration. The solids were slury-washed with hot ethanol, cooled, collected by vacuum filtration and dried under vacuum at 40° C. overnight to give 1.5 g (45% yield) of 5-isopropylaminosulfonyl-2-oxindole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06706709B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-e44dac7950b54d20b6484291d6c3b65b |
| Source note | uspto-grants-2004_03 |